EP1233075A3 - BDNF polymorphism and association with bipolar disorder - Google Patents

BDNF polymorphism and association with bipolar disorder Download PDF

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Publication number
EP1233075A3
EP1233075A3 EP02251007A EP02251007A EP1233075A3 EP 1233075 A3 EP1233075 A3 EP 1233075A3 EP 02251007 A EP02251007 A EP 02251007A EP 02251007 A EP02251007 A EP 02251007A EP 1233075 A3 EP1233075 A3 EP 1233075A3
Authority
EP
European Patent Office
Prior art keywords
bipolar disorder
association
bdnf
polymorphism
neuropsychiatric disorders
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02251007A
Other languages
German (de)
French (fr)
Other versions
EP1233075A2 (en
Inventor
Pamela Sklar
Eric S. Lander
Raymond J. Depaulo, Jr.
Melvin G. Mcinnis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Johns Hopkins University
Whitehead Institute for Biomedical Research
Original Assignee
General Hospital Corp
Johns Hopkins University
Whitehead Institute for Biomedical Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by General Hospital Corp, Johns Hopkins University, Whitehead Institute for Biomedical Research filed Critical General Hospital Corp
Publication of EP1233075A2 publication Critical patent/EP1233075A2/en
Publication of EP1233075A3 publication Critical patent/EP1233075A3/en
Withdrawn legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Methods for diagnosing and treating neuropsychiatric disorders, especially bipolar disorder, and to methods for identifying compounds for use in the diagnosis and treatment of neuropsychiatric disorders are disclosed. Also disclosed are novel compounds and pharmaceutical compositions for use in the diagnosis and treatment of neuropsychiatric disorders such as bipolar disorder.
EP02251007A 2001-02-15 2002-02-14 BDNF polymorphism and association with bipolar disorder Withdrawn EP1233075A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26905901P 2001-02-15 2001-02-15
US269059P 2001-02-15

Publications (2)

Publication Number Publication Date
EP1233075A2 EP1233075A2 (en) 2002-08-21
EP1233075A3 true EP1233075A3 (en) 2003-01-08

Family

ID=23025625

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02251007A Withdrawn EP1233075A3 (en) 2001-02-15 2002-02-14 BDNF polymorphism and association with bipolar disorder

Country Status (2)

Country Link
US (1) US20030157493A1 (en)
EP (1) EP1233075A3 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7127290B2 (en) * 1999-10-01 2006-10-24 Cardiac Pacemakers, Inc. Cardiac rhythm management systems and methods predicting congestive heart failure status
US7101666B2 (en) 2001-08-31 2006-09-05 Centre For Addiction And Mental Health Involvement of the BDNF gene in mood disorders
EP1573039A4 (en) * 2002-11-01 2008-04-16 Univ Leland Stanford Junior COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING MOOD DISORDERS
DK1766077T3 (en) 2004-06-21 2012-07-16 Univ Leland Stanford Junior Differentially expressed genes and pathways in bipolar disorder and / or severe depressive disorder
US7386345B2 (en) * 2005-01-27 2008-06-10 Cardiac Pacemakers, Inc. Apparatus and method for temporary treatment of acute heart failure decompensation
CA2629299C (en) 2005-11-12 2017-08-22 The Board Of Trustees Of The Leland Stanford Junior University Fgf2-related methods for diagnosing and treating depression

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1001037A2 (en) * 1998-09-28 2000-05-17 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
WO2001011085A2 (en) * 1999-08-11 2001-02-15 Whitehead Institute For Biomedical Research Bdnf polymorphism and association with bipolar disorder

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606031A (en) * 1990-04-06 1997-02-25 Lile; Jack Production and purification of biologically active recombinant neurotrophic protein in bacteria
US5235043A (en) * 1990-04-06 1993-08-10 Synergen, Inc. Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins
US5986070A (en) * 1990-04-06 1999-11-16 Amgen Inc. Production of biologically active NGF proteins
DE4224759C2 (en) * 1992-07-27 2002-04-18 Ina Schaeffler Kg Tensioning system, friction damped for belt or chain drives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1001037A2 (en) * 1998-09-28 2000-05-17 Whitehead Institute For Biomedical Research Pre-selection and isolation of single nucleotide polymorphisms
WO2001011085A2 (en) * 1999-08-11 2001-02-15 Whitehead Institute For Biomedical Research Bdnf polymorphism and association with bipolar disorder

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CRONIN M T ET AL: "APPLYING RAPID DNA MICROARRAY OPTIMIZATION CAPABILITY TO SNP SCREENING AND GENOTYPING", AMERICAN JOURNAL OF HUMAN GENETICS, UNIVERSITY OF CHICAGO PRESS, CHICAGO,, US, vol. 4, no. 65, October 1999 (1999-10-01), pages A244, XP008006599, ISSN: 0002-9297 *
GERHOLD D ET AL: "DNA chips: promising toys have become powerful tools.", TRENDS IN BIOCHEMICAL SCIENCES. ENGLAND MAY 1999, vol. 24, no. 5, May 1999 (1999-05-01), pages 168 - 173, XP002216096, ISSN: 0968-0004 *
KREBS M O ET AL: "ASSOCIATION STUDY OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) POLYMORPHISM IN SCHIZOPHRENIA", AMERICAN JOURNAL OF MEDICAL GENETICS, NEW YORK,NY, US, vol. 81, no. 6, 1998, pages 520, XP000990211 *
MCCARTHY J J ET AL: "THE USE OF SINGLE-NUCLEOTIDE POLYMORPHISM MAPS IN PHARMACOGENOMICS", NATURE BIOTECHNOLOGY, NATURE PUB. CO, NEW YORK, NY, US, vol. 18, May 2000 (2000-05-01), pages 505 - 508, XP000941628, ISSN: 1087-0156 *
SAPOLSKY R J ET AL: "High-throughput polymorphism screening and genotyping with high-density oligonucleotide arrays", GENETIC ANALYSIS: BIOMOLECULAR ENGINEERING, ELSEVIER SCIENCE PUBLISHING, US, vol. 14, no. 5-6, February 1999 (1999-02-01), pages 187 - 192, XP004158703, ISSN: 1050-3862 *
SKLAR P ET AL: "Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus.", MOLECULAR PSYCHIATRY, vol. 7, no. 6, 2002, 2002, pages 579 - 593, XP002216091, ISSN: 1359-4184 *

Also Published As

Publication number Publication date
EP1233075A2 (en) 2002-08-21
US20030157493A1 (en) 2003-08-21

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