EP4324921A3 - Biointerface layer for analyte sensors - Google Patents

Biointerface layer for analyte sensors Download PDF

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Publication number
EP4324921A3
EP4324921A3 EP23207670.3A EP23207670A EP4324921A3 EP 4324921 A3 EP4324921 A3 EP 4324921A3 EP 23207670 A EP23207670 A EP 23207670A EP 4324921 A3 EP4324921 A3 EP 4324921A3
Authority
EP
European Patent Office
Prior art keywords
sensor
biointerface
analyte
biointerface layer
sensing membrane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP23207670.3A
Other languages
German (de)
French (fr)
Other versions
EP4324921A2 (en
Inventor
Ted Tang Lee
Andrew Trinin Dennis
Shanger Wang
Jiong Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dexcom Inc
Original Assignee
Dexcom Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dexcom Inc filed Critical Dexcom Inc
Publication of EP4324921A2 publication Critical patent/EP4324921A2/en
Publication of EP4324921A3 publication Critical patent/EP4324921A3/en
Pending legal-status Critical Current

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    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3273—Devices therefor, e.g. test element readers, circuitry
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
    • A61B5/002—Monitoring the patient using a local or closed circuit, e.g. in a room or building
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction

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Abstract

Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises a biointerface layer which interfaces with a biological fluid containing the analyte to be measured. The biointerface layer comprises a biointerface polymer, wherein the biointerface polymer comprises polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The biointerface layer increases sensor longevity and decrease sensor inaccuracy by inhibiting accumulation of cells, proteins, and other biological species on the outermost layers of the sensor.
EP23207670.3A 2015-12-30 2016-12-29 Biointerface layer for analyte sensors Pending EP4324921A3 (en)

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US201562273155P 2015-12-30 2015-12-30
US201562273142P 2015-12-30 2015-12-30
US201562273219P 2015-12-30 2015-12-30
EP16882715.2A EP3397398B1 (en) 2015-12-30 2016-12-29 Biointerface layer for analyte sensors
PCT/US2016/069348 WO2017117472A1 (en) 2015-12-30 2016-12-29 Biointerface layer for analyte sensors

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EP4324921A3 true EP4324921A3 (en) 2024-05-01

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EP16882712.9A Active EP3397163B1 (en) 2015-12-30 2016-12-29 Diffusion resistance layer for analyte sensors
EP21157321.7A Active EP3895614B1 (en) 2015-12-30 2016-12-29 Enzyme immobilized adhesive layer for analyte sensors
EP23150421.8A Pending EP4218566A1 (en) 2015-12-30 2016-12-29 Enzyme immobilized adhesive layer for analyte sensors
EP23207670.3A Pending EP4324921A3 (en) 2015-12-30 2016-12-29 Biointerface layer for analyte sensors
EP23184439.0A Pending EP4253536A3 (en) 2015-12-30 2016-12-29 Diffusion resistance layer for analyte sensors
EP16882715.2A Active EP3397398B1 (en) 2015-12-30 2016-12-29 Biointerface layer for analyte sensors
EP16882711.1A Active EP3397397B1 (en) 2015-12-30 2016-12-29 Enzyme immobilized adhesive layer for analyte sensors
EP16882775.6A Active EP3397162B1 (en) 2015-12-30 2016-12-30 Membrane layers for analyte sensors
EP23181721.4A Pending EP4292528A1 (en) 2015-12-30 2016-12-30 Membrane layers for analyte sensors

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EP23184439.0A Pending EP4253536A3 (en) 2015-12-30 2016-12-29 Diffusion resistance layer for analyte sensors
EP16882715.2A Active EP3397398B1 (en) 2015-12-30 2016-12-29 Biointerface layer for analyte sensors
EP16882711.1A Active EP3397397B1 (en) 2015-12-30 2016-12-29 Enzyme immobilized adhesive layer for analyte sensors
EP16882775.6A Active EP3397162B1 (en) 2015-12-30 2016-12-30 Membrane layers for analyte sensors
EP23181721.4A Pending EP4292528A1 (en) 2015-12-30 2016-12-30 Membrane layers for analyte sensors

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AU (14) AU2016381965B2 (en)
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CA2994318C (en) 2023-09-19
AU2021211973A1 (en) 2021-08-26
EP3397163B1 (en) 2023-09-13
EP4218566A1 (en) 2023-08-02
JP7184643B2 (en) 2022-12-06
AU2021257924A1 (en) 2021-11-18
CA3203953A1 (en) 2017-07-06
EP4253536A3 (en) 2023-12-20
JP6983765B2 (en) 2021-12-17
EP3397162A4 (en) 2019-06-26
AU2016381968A1 (en) 2018-04-26
AU2021257924B2 (en) 2023-08-31
CA3003533A1 (en) 2017-07-06
AU2019253773A1 (en) 2019-11-07
US11262326B2 (en) 2022-03-01
AU2016381362B2 (en) 2019-02-28
AU2016381965A1 (en) 2018-04-26
AU2016381965B2 (en) 2019-07-25
AU2021211973B2 (en) 2023-06-01
JP2023022148A (en) 2023-02-14
JP2019506910A (en) 2019-03-14
EP3397162A1 (en) 2018-11-07
WO2017117472A1 (en) 2017-07-06
AU2016381362A1 (en) 2018-02-22
EP3397163A1 (en) 2018-11-07
EP4292528A1 (en) 2023-12-20
AU2022218567B2 (en) 2024-09-19
AU2016381968B2 (en) 2020-03-19
US20230139158A1 (en) 2023-05-04
US20240138720A1 (en) 2024-05-02
US11112377B2 (en) 2021-09-07
JP7404325B2 (en) 2023-12-25
JP2022028855A (en) 2022-02-16
US20170191955A1 (en) 2017-07-06
EP3895614A1 (en) 2021-10-20
US20170188916A1 (en) 2017-07-06
AU2019203726B2 (en) 2020-04-02
AU2019203726A1 (en) 2019-06-20
JP7258953B2 (en) 2023-04-17
AU2023270293A1 (en) 2023-12-14
WO2017117565A1 (en) 2017-07-06
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EP3397398A1 (en) 2018-11-07

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