US6416554B1 - Lung reduction apparatus and method - Google Patents

Lung reduction apparatus and method Download PDF

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Publication number
US6416554B1
US6416554B1 US09/379,973 US37997399A US6416554B1 US 6416554 B1 US6416554 B1 US 6416554B1 US 37997399 A US37997399 A US 37997399A US 6416554 B1 US6416554 B1 US 6416554B1
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Prior art keywords
jacket
lung
collapsing
lung portion
cord
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US09/379,973
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Clifton A. Alferness
Richard Y. Lin
Wilfred E. Jaeger
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Gyrus ACMI Inc
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Spiration Inc
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Assigned to SPIRATION, INC. reassignment SPIRATION, INC. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: LIN, RICHARD Y., ALFERNESS, CLIFTON A., JAEGER, WILFRED E.
Priority to US09/379,973 priority Critical patent/US6416554B1/en
Priority to ES00118072T priority patent/ES2272225T3/en
Priority to DE60031052T priority patent/DE60031052T2/en
Priority to EP00118072A priority patent/EP1078601B1/en
Priority to AT00118072T priority patent/ATE341278T1/en
Priority to CA002316707A priority patent/CA2316707C/en
Priority to JP2000253750A priority patent/JP3728192B2/en
Priority to AU53611/00A priority patent/AU772041B2/en
Publication of US6416554B1 publication Critical patent/US6416554B1/en
Application granted granted Critical
Priority to US10/199,776 priority patent/US20020188171A1/en
Anticipated expiration legal-status Critical
Assigned to GYRUS ACMI, INC. reassignment GYRUS ACMI, INC. MERGER (SEE DOCUMENT FOR DETAILS). Assignors: SPIRATION, INC.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods
    • A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes

Definitions

  • the present invention is generally directed to an apparatus and method for treating Chronic Obstructive Pulmonary Disease (COPD).
  • COPD Chronic Obstructive Pulmonary Disease
  • the present invention is more particularly directed to such an apparatus and method which may be implanted in the human body to provide lung size reduction by constricting at least a portion of a lung.
  • COPD Chronic Obstructive Pulmonary Disease
  • COPD chronic obstructive pulmonary disease
  • COPD chronic obstructive pulmonary disease
  • Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below.
  • Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled ⁇ -agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, Ipratropium bromide may be indicated. Further, courses of steroids, such as corticosterocds, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pheumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
  • LVRS lung volume reduction surgery
  • Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricular filling.
  • lung tranplantation is also an option.
  • COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
  • the present invention provides an implantable apparatus for reducing the size of a lung.
  • the apparatus includes a jacket of flexible fabric configured to cover at least a portion of a lung and collapsing means carried by the jacket for collapsing the jacket about the lung portion.
  • the invention still further provides a method of reducing the size of a lung.
  • the method includes the steps of disposing a jacket of flexible fabric over at least a portion of a lung.
  • the collapsing of the jacket may serve to both reduce the size of the lung and maintain it in its reduced size condition.
  • the lung portion may first be deflated whereupon the collapsed jacket serves to maintain the lung portion in a deflated, reduced size condition.
  • FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system
  • FIG. 2 is a sectional view similar to FIG. 1 but illustrating a respiratory system suffering from COPD;
  • FIG. 3 is a perspective view illustrating a lung constriction apparatus embodying the present invention
  • FIG. 4 is a sectional view of the respiratory system of FIG. 2 with a lung constriction apparatus embodying the present invention being disposed over a lung portion to be reduced in size;
  • FIG. 5 illustrates an initial step in collapsing the lung constricting apparatus about the lung portion
  • FIG. 6 illustrates a further step in collapsing the lung constriction apparatus
  • FIG. 7 illustrates the lung constricting apparatus being fully collapsed about the lung portion
  • FIG. 8 illustrates the respiratory system after both left and right side lung portions have been reduced in size in accordance with the present invention.
  • FIG. 1 it is a sectional view of a healthy respiratory system.
  • the respiratory system 20 resides within the thorax 22 which occupies a space defined by the chest wall 24 and the diaphragm 26 .
  • the respiratory system 20 includes the trachea 28 , the left mainstem bronchus 30 , the right mainstem bronchus 32 , and the bronchial branches 34 , 36 , 38 , 40 , and 42 .
  • the respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56 , 58 , and 60 .
  • Each bronchial branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof.
  • Characteristic of a healthy respiratory system is the arched or inwardly arcuate diaphragm 26 .
  • the diaphragm 26 straightens to increase the volume of the thorax 22 . This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air.
  • the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.
  • FIG. 2 illustrates a respiratory system suffering from COPD.
  • the lung lobes 52 , 54 , 56 , 58 , and 60 are enlarged and that the diaphragm 26 is not arched but substantially straight.
  • this individual is incapable of breathing normally by moving the diaphragm 28 .
  • this individual in order to create the negative pressure in the thorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths.
  • apex portion 62 and 66 of the upper lung lobes 52 and 56 are most affected by COPD.
  • the preferred embodiment will be described for treating the apex 66 of the right, upper lung lobe 56 .
  • the present invention may be applied to any lung portion without departing from the present invention.
  • the apparatus and method of the present invention treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing lung volume reduction surgery.
  • the present invention contemplates permanent collapse of a lung portion or lung portions most affected. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
  • FIG. 3 it illustrates a lung constriction apparatus 70 embodying the present invention.
  • the apparatus 70 takes the form of a jacket 72 formed of a flexible fabric such as an open mesh of polyester.
  • the jacket includes an open base 74 and a curved surface 76 extending from the open base 74 and terminating in a closed, domed-shape end or apex 78 .
  • the open base 74 is dimensioned to be applied over and to cover the lung portion to be reduced in size.
  • the constriction apparatus 70 further includes at least one lace 80 extending from the apex 78 to the base 74 .
  • the cord 82 forming the lace 80 has a pair of free ends 84 and 86 which are threaded through a guide tube 88 from the distal end 90 of the guide tube 88 to the proximal end 92 of the guide tube 88 .
  • the guide tube 88 serves to maintain the free ends 84 and 86 of the cord 82 together.
  • the jacket 72 is collapsed to reduce the inner volume of the jacket. This constriction of the jacket serves to collapse the jacket about the lung portion to be reduced in size.
  • a plurality of laces may be carried by the jacket. As each lace is drawn, the jacket will be collapsed to a greater and controlled extent.
  • the jacket 72 further includes a piping 94 at the base 74 .
  • a draw string 96 is threaded through the piping to circumscribe the jacket 72 and the base 74 .
  • the draw string has a pair of free ends 98 and 100 .
  • the free ends 98 and 100 of the draw string 96 may be pulled and drawn to close the open base 74 of the jacket 72 about the lung portion. This will provide additional constriction to assure that the lung portion does not reinflate. It also serves to cut off all blood circulation to the lung portion. This promotes infarction and fibrosis.
  • FIG. 4 it illustrates the constriction device 70 after it has been placed over the apex of the upper right lung lobe 56 to cover the lung portion 66 of the right upper lobe 56 referred to previously with respect to FIG. 2 .
  • the jacket 72 covers the lung portion 66 .
  • the free ends 84 and 86 of the cord forming the lace 80 have not been drawn.
  • the lace 80 has been drawn by the pulling of the free ends 84 and 86 of the lace cord while holding the guide tube 88 such that its distal end 90 is closely adjacent the base 74 of the jacket 72 .
  • the jacket 72 has been collapsed about the lung portion 66 of the upper lobe 56 , the lung portion 66 has been reduced in size due to the constriction of the jacket 72 .
  • FIG. 6 illustrates the jacket 72 with additional laces 110 and 112 which have also been drawn.
  • the laces When the laces are drawn tightly, the free ends of the cords forming the laces may be tied off and then cut as illustrated.
  • the lung portion 66 of the upper right lobe 56 is now more fully reduced in size by the constriction of the jacket 72 .
  • FIG. 7 illustrates the further constriction provided by the drawstring after being pulled.
  • the free ends of the drawstring after being pulled may be then tied together and cut as illustrated.
  • the lung portion 66 of the upper right lobe 56 has been drastically reduced in size. Further, the drawstring constriction will cut off circulation to the lung portion 66 to promote infarction and fibrosis.
  • FIG. 8 illustrates the respiratory system after both the lung portion 66 of the upper right lobe 56 and the lung portion 62 of the upper left lobe 52 have been treated as described above.
  • the volumes of the right upper lung lobe 56 and left upper lung lobe 52 have been reduced in size by the jacket 72 .
  • This causes the lung lobes to occupy less volume within the thorax 22 to permit the diaphragm 26 to assume its arched state for acting upon the remaining healthier lung tissue.
  • this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
  • the present invention provides an apparatus and method for treating COPD by lung volume reduction.
  • the lung volume reduction is achieved through the permanent collapsing of one or more lung portions, or lobes, or portions of lobes.
  • the foregoing is achieved without the need for removing lung tissue.
  • the lung tissue within the thorax will occupy a lesser volume than previously occupied providing room for the diaphragm to assume its arcuate state to assist in normal breathing and to achieve the benefits of lung volume reduction.
  • the jacket may be employed for reducing the size of a lung by constriction, the invention is not intended to be so limited. Rather, the lung portion may become deflated during surgery on its own or by other means known in the art. The jacket may then be placed on the lung portion while it is in a deflated condition. The jacket may then be collapsed about the lung portion to cinch down over the lung to maintain it in its deflated, reduced volume condition. The jacket would thus prevent re-expansion of the captured lung portion. The remaining portions of the lung may then be expanded, if necessary, by means known in the art. Hence, it is intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.

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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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Abstract

An apparatus and method reduces the size of a lung. The apparatus includes a jacket of flexible fabric configured to cover at least a portion of the lung. A lace, carried by the jacket, collapses the jacket about the lung portion. The jacket may further include a drawstring circumscribing the jacket at the base for closing the open base of the jacket about the lung portion. The collapsing of the jacket may be employed for both reducing the size of the lung and maintaining the lung in a reduced size condition or the lung portion may be deflated prior to the placement of the jacket over the lung portion, in which case, the jacket serves to prevent re-expansion of the lung portion.

Description

BACKGROUND OF THE INVENTION
The present invention is generally directed to an apparatus and method for treating Chronic Obstructive Pulmonary Disease (COPD). The present invention is more particularly directed to such an apparatus and method which may be implanted in the human body to provide lung size reduction by constricting at least a portion of a lung.
Chronic Obstructive Pulmonary Disease (COPD) has become a major cause of morbidity and mortality in the United States over the last three decades. COPD is characterized by the presence of airflow obstruction due to chronic bronchitis or emphysema. The airflow obstruction in COPD is due largely to structural abnormalities in the smaller airways. Important causes are inflammation, fibrosis, goblet cell metaplasia, and smooth muscle hypertrophy in terminal bronchioles.
The incidence, prevalence, and health-related costs of COPD are on the rise. Mortality due to COPD is also on the rise. In 1991 COPD was the fourth leading cause of death in the United States and had increased 33% since 1979.
COPD affects the patient's whole life. It has three main symptoms: cough; breathlessness; and wheeze. At first, breathlessness may be noticed when running for a bus, digging in the garden, or walking up hill. Later, it may be noticed when simply walking in the kitchen. Overtime, it may occur with less and less effort until it is present all of the time.
COPD is a progressive disease and currently has no cure. Current treatments for COPD include the prevention of further respiratory damage, pharmacotherapy, and surgery. Each is discussed below.
The prevention of further respiratory damage entails the adoption of a healthy lifestyle. Smoking cessation is believed to be the single most important therapeutic intervention. However, regular exercise and weight control are also important. Patients whose symptoms restrict their daily activities or who otherwise have an impaired quality of life may require a pulmonary rehabilitation program including ventilatory muscle training and breathing retraining. Long-term oxygen therapy may also become necessary.
Pharmacotherapy may include bronchodilator therapy to open up the airways as much as possible or inhaled β-agonists. For those patients who respond poorly to the foregoing or who have persistent symptoms, Ipratropium bromide may be indicated. Further, courses of steroids, such as corticosterocds, may be required. Lastly, antibiotics may be required to prevent infections and influenza and pheumococcal vaccines may be routinely administered. Unfortunately, there is no evidence that early, regular use of pharmacotherapy will alter the progression of COPD.
About 40 years ago, it was first postulated that the tethering force that tends to keep the intrathoracic airways open was lost in emphysema and that by surgically removing the most affected parts of the lungs, the force could be partially restored. Although the surgery was deemed promising, the procedure was abandoned.
The lung volume reduction surgery (LVRS) was later revived. In the early 1990's, hundreds of patients underwent the procedure. However, the procedure has fallen out of favor due to the fact that Medicare stopped remitting for LVRS. Unfortunately, data is relatively scarce and many factors conspire to make what data exists difficult to interpret. The procedure is currently under review in a controlled clinical trial. However, what data does exist tends to indicate that patients benefited from the procedure in terms of an increase in forced expiratory volume, a decrease in total lung capacity, and a significant improvement in lung function, dyspnea, and quality of life.
Improvements in pulmonary function after LVRS have been attributed to at least four possible mechanisms. These include enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricular filling.
Lastly, lung tranplantation is also an option. Today, COPD is the most common diagnosis for which lung transplantation is considered. Unfortunately, this consideration is given for only those with advanced COPD. Given the limited availability of donor organs, lung transplant is far from being available to all patients.
In view of the foregoing, there in a need in the art for a new and improved therapy for COPD. More specifically, there is a need for such a therapy which provides more permanent results than pharmacotherapy while being less traumatic than LVRS. The present invention is directed to an apparatus and method which provide such an improved therapy for COPD.
SUMMARY OF THE INVENTION
The present invention provides an implantable apparatus for reducing the size of a lung. The apparatus includes a jacket of flexible fabric configured to cover at least a portion of a lung and collapsing means carried by the jacket for collapsing the jacket about the lung portion.
The invention still further provides a method of reducing the size of a lung. The method includes the steps of disposing a jacket of flexible fabric over at least a portion of a lung. The collapsing of the jacket may serve to both reduce the size of the lung and maintain it in its reduced size condition. Alternatively, the lung portion may first be deflated whereupon the collapsed jacket serves to maintain the lung portion in a deflated, reduced size condition.
BRIEF DESCRIPTION OF THE DRAWINGS
The features of the present invention which are believed to be novel are set forth with particularity in the appended claims. The invention, together with further objects and advantages thereof, may best be understood by making reference to the following description taken in conjunction with the accompanying drawings, in the several figures of which like referenced numerals identify identical elements, and wherein:
FIG. 1 is a simplified sectional view of a thorax illustrating a healthy respiratory system;
FIG. 2 is a sectional view similar to FIG. 1 but illustrating a respiratory system suffering from COPD;
FIG. 3 is a perspective view illustrating a lung constriction apparatus embodying the present invention;
FIG. 4 is a sectional view of the respiratory system of FIG. 2 with a lung constriction apparatus embodying the present invention being disposed over a lung portion to be reduced in size;
FIG. 5 illustrates an initial step in collapsing the lung constricting apparatus about the lung portion;
FIG. 6 illustrates a further step in collapsing the lung constriction apparatus;
FIG. 7 illustrates the lung constricting apparatus being fully collapsed about the lung portion; and
FIG. 8 illustrates the respiratory system after both left and right side lung portions have been reduced in size in accordance with the present invention.
DETAILED DESCRIPTION
Referring now to FIG. 1, it is a sectional view of a healthy respiratory system. The respiratory system 20 resides within the thorax 22 which occupies a space defined by the chest wall 24 and the diaphragm 26.
The respiratory system 20 includes the trachea 28, the left mainstem bronchus 30, the right mainstem bronchus 32, and the bronchial branches 34, 36, 38, 40, and 42. The respiratory system 20 further includes left lung lobes 52 and 54 and right lung lobes 56, 58, and 60. Each bronchial branch communicates with a respective different portion of a lung lobe, either the entire lung lobe or a portion thereof.
Characteristic of a healthy respiratory system is the arched or inwardly arcuate diaphragm 26. As the individual inhales, the diaphragm 26 straightens to increase the volume of the thorax 22. This causes a negative pressure within the thorax. The negative pressure within the thorax in turn causes the lung lobes to fill with air. When the individual exhales, the diaphragm returns to its original arched condition to decrease the volume of the thorax. The decreased volume of the thorax causes a positive pressure within the thorax which in turn causes exhalation of the lung lobes.
In contrast to the healthy respiratory system of FIG. 1, FIG. 2 illustrates a respiratory system suffering from COPD. Here it may be seen that the lung lobes 52, 54, 56, 58, and 60 are enlarged and that the diaphragm 26 is not arched but substantially straight. Hence, this individual is incapable of breathing normally by moving the diaphragm 28. Instead, in order to create the negative pressure in the thorax 22 required for breathing, this individual must move the chest wall outwardly to increase the volume of the thorax. This results in inefficient breathing causing these individuals to breathe rapidly with shallow breaths.
It has been found that the apex portion 62 and 66 of the upper lung lobes 52 and 56, respectively, are most affected by COPD. Hence, the preferred embodiment will be described for treating the apex 66 of the right, upper lung lobe 56. However, as will be appreciated by those skilled in the art, the present invention may be applied to any lung portion without departing from the present invention.
The apparatus and method of the present invention treats COPD by deriving the benefits of lung volume reduction surgery without the need of performing lung volume reduction surgery. As will be seen hereinafter, the present invention contemplates permanent collapse of a lung portion or lung portions most affected. This leaves extra volume within the thorax for the diaphragm to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
Referring now to FIG. 3, it illustrates a lung constriction apparatus 70 embodying the present invention. The apparatus 70 takes the form of a jacket 72 formed of a flexible fabric such as an open mesh of polyester. The jacket includes an open base 74 and a curved surface 76 extending from the open base 74 and terminating in a closed, domed-shape end or apex 78. The open base 74 is dimensioned to be applied over and to cover the lung portion to be reduced in size.
The constriction apparatus 70 further includes at least one lace 80 extending from the apex 78 to the base 74. The cord 82 forming the lace 80 has a pair of free ends 84 and 86 which are threaded through a guide tube 88 from the distal end 90 of the guide tube 88 to the proximal end 92 of the guide tube 88.
The guide tube 88 serves to maintain the free ends 84 and 86 of the cord 82 together. When the free ends 84 and 86 of the cord 82 are drawn while holding the guide tube distal end 90 adjacent the base 74, the jacket 72 is collapsed to reduce the inner volume of the jacket. This constriction of the jacket serves to collapse the jacket about the lung portion to be reduced in size.
As will be seen hereinafter, a plurality of laces may be carried by the jacket. As each lace is drawn, the jacket will be collapsed to a greater and controlled extent.
The jacket 72 further includes a piping 94 at the base 74. A draw string 96 is threaded through the piping to circumscribe the jacket 72 and the base 74. The draw string has a pair of free ends 98 and 100. As will be seen hereinafter, after the laces are drawn to collapse the jacket 72 about the lung portion, the free ends 98 and 100 of the draw string 96 may be pulled and drawn to close the open base 74 of the jacket 72 about the lung portion. This will provide additional constriction to assure that the lung portion does not reinflate. It also serves to cut off all blood circulation to the lung portion. This promotes infarction and fibrosis.
Referring now to FIG. 4, it illustrates the constriction device 70 after it has been placed over the apex of the upper right lung lobe 56 to cover the lung portion 66 of the right upper lobe 56 referred to previously with respect to FIG. 2. The jacket 72 covers the lung portion 66. At this point, the free ends 84 and 86 of the cord forming the lace 80 have not been drawn.
Referring now to FIG. 5, here it may be seen that the lace 80 has been drawn by the pulling of the free ends 84 and 86 of the lace cord while holding the guide tube 88 such that its distal end 90 is closely adjacent the base 74 of the jacket 72. As will be observed in FIG. 5, because the jacket 72 has been collapsed about the lung portion 66 of the upper lobe 56, the lung portion 66 has been reduced in size due to the constriction of the jacket 72.
FIG. 6 illustrates the jacket 72 with additional laces 110 and 112 which have also been drawn. When the laces are drawn tightly, the free ends of the cords forming the laces may be tied off and then cut as illustrated. The lung portion 66 of the upper right lobe 56 is now more fully reduced in size by the constriction of the jacket 72.
FIG. 7 illustrates the further constriction provided by the drawstring after being pulled. The free ends of the drawstring after being pulled may be then tied together and cut as illustrated. As can be seen in FIG. 7, the lung portion 66 of the upper right lobe 56 has been drastically reduced in size. Further, the drawstring constriction will cut off circulation to the lung portion 66 to promote infarction and fibrosis.
FIG. 8 illustrates the respiratory system after both the lung portion 66 of the upper right lobe 56 and the lung portion 62 of the upper left lobe 52 have been treated as described above. Here it can be seen that the volumes of the right upper lung lobe 56 and left upper lung lobe 52 have been reduced in size by the jacket 72. This causes the lung lobes to occupy less volume within the thorax 22 to permit the diaphragm 26 to assume its arched state for acting upon the remaining healthier lung tissue. As previously mentioned, this should result in improved pulmonary function due to enhanced elastic recoil, correction of ventilation/perfusion mismatch, improved efficiency of respiratory musculature, and improved right ventricle filling.
As can thus be seen from the foregoing, the present invention provides an apparatus and method for treating COPD by lung volume reduction. The lung volume reduction is achieved through the permanent collapsing of one or more lung portions, or lobes, or portions of lobes. The foregoing is achieved without the need for removing lung tissue. Following the treatment, the lung tissue within the thorax will occupy a lesser volume than previously occupied providing room for the diaphragm to assume its arcuate state to assist in normal breathing and to achieve the benefits of lung volume reduction.
While particular embodiments of the present invention have been shown and described, modifications may be made. For example, while the jacket may be employed for reducing the size of a lung by constriction, the invention is not intended to be so limited. Rather, the lung portion may become deflated during surgery on its own or by other means known in the art. The jacket may then be placed on the lung portion while it is in a deflated condition. The jacket may then be collapsed about the lung portion to cinch down over the lung to maintain it in its deflated, reduced volume condition. The jacket would thus prevent re-expansion of the captured lung portion. The remaining portions of the lung may then be expanded, if necessary, by means known in the art. Hence, it is intended in the appended claims to cover all such changes and modifications which fall within the true spirit and scope of the invention.

Claims (18)

What is claimed is:
1. An implantable apparatus for reducing the size of a lung comprising:
a jacket of flexible fabric configured to be implanted and to cover only a portion of a lung; and
collapsing means for collapsing the jacket about the lung portion to collapse the lung portion.
2. The apparatus of claim 1 wherein the flexible fabric is an open mesh material.
3. The apparatus of claim 1 wherein the jacket includes an opening for applying the jacket to the lung portion, and a closed end.
4. An implantable apparatus for reducing the size of a lung comprising:
a jacket of flexible fabric configured to be implanted and to cover at least a portion of a lung; and
collapsing means for collapsing the jacket about the lung portion, the jacket including an opening for applying the jacket to the lung portion, and a base defining the opening and being dimensioned to be applied over and to cover the lung portion to be reduced in size.
5. The apparatus of claim 4 wherein the collapsing means is carried by the jacket and comprises at least one lace extending from the closed end towards the base, the at least one lace including a cord having a pair of free ends which, when drawn, collapse the jacket about the lung portion.
6. The apparatus of claim 5 further including a guide tube having a distal end and a proximal end and wherein the free ends of the cord are threaded from the distal end of the guide tube to and through the proximal end of the guide tube.
7. The apparatus of claim 6 wherein the distal end of the guide tube is closely adjacent the base of the jacket.
8. The apparatus of claim 4 wherein the collapsing means includes a draw string circumscribing the jacket at the base, the draw string having a pair of free ends which, when drawn, close the open base of the jacket about the lung portion.
9. The apparatus of claim 1 wherein the flexible fabric is formed of polyester.
10. A method of reducing the size of a lung, the method including the steps of:
disposing a jacket of flexible fabric over only a portion of a lung; and
collapsing the jacket about the lung portion to collapse the lung portion.
11. The method of claim 10 wherein the flexible fabric is an open mesh material.
12. The method of claim 11 wherein the open mesh material is a polyester mesh.
13. The method of claim 10 including the step of providing the jacket with a closed end and an opening to permit disposing the jacket over the lung portion.
14. A method of reducing the size of a lung, the method including the steps of:
disposing a jacket of flexible fabric over at least a portion of a lung;
providing the jacket with a closed end and an opening to permit disposing the jacket over the lung portion; and
collapsing the jacket about the lung portion to collapse the lung portion, wherein the collapsing step includes lacing a cord on the jacket from the closed end towards the opening, the cord when laced having a pair of free ends, and pulling on the free ends of the cord to cause the jacket to collapse about the lung portion.
15. The method of claim 14 wherein the collapsing step further includes tying the free ends of the cord together after the jacket is collapsed about the lung portion.
16. A method of reducing the size of a lung, the method including the steps of:
disposing a jacket of flexible fabric over at least a portion of a lung;
providing the jacket with a closed end and an opening to permit disposing the jacket over the lung portion; and
collapsing the jacket about the lung portion to collapse the lung portion, wherein the collapsing step includes circumscribing the opening with a cord, the cord having a pair of free ends, and pulling on the free ends of the cord to collapse the opening of the jacket about the lung portion.
17. The method of claim 16 wherein the collapsing step further includes tying the free ends of the cord together after the opening of the jacket is collapsed about the lung portion.
18. The method of claim 10 including the further step of deflating the lung portion prior to disposing the jacket over the lung portion.
US09/379,973 1999-08-24 1999-08-24 Lung reduction apparatus and method Expired - Lifetime US6416554B1 (en)

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US09/379,973 US6416554B1 (en) 1999-08-24 1999-08-24 Lung reduction apparatus and method
ES00118072T ES2272225T3 (en) 1999-08-24 2000-08-23 LUNG VOLUME REDUCTION KIT.
DE60031052T DE60031052T2 (en) 1999-08-24 2000-08-23 Set for reducing the lung volume
EP00118072A EP1078601B1 (en) 1999-08-24 2000-08-23 Kit for lung volume reduction
AT00118072T ATE341278T1 (en) 1999-08-24 2000-08-23 LUNG VOLUME REDUCTION SET
CA002316707A CA2316707C (en) 1999-08-24 2000-08-23 Lung reduction apparatus and method
JP2000253750A JP3728192B2 (en) 1999-08-24 2000-08-24 Lung stenosis device
AU53611/00A AU772041B2 (en) 1999-08-24 2000-08-24 Lung reduction apparatus and method
US10/199,776 US20020188171A1 (en) 1999-08-24 2002-07-18 Lung reduction apparatus and method

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Cited By (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020077696A1 (en) * 1997-09-16 2002-06-20 Gholam-Reza Zadno-Azizi Body fluid flow control device
US6514290B1 (en) * 2000-03-31 2003-02-04 Broncus Technologies, Inc. Lung elastic recoil restoring or tissue compressing device and method
US20030069488A1 (en) * 2001-07-10 2003-04-10 Spiration, Inc. Constriction device including fixation structure
US20030070683A1 (en) * 2000-03-04 2003-04-17 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20030192551A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030228344A1 (en) * 2002-03-08 2003-12-11 Fields Antony J. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20040030335A1 (en) * 2002-05-14 2004-02-12 University Of Pittsburgh Device and method of use for functional isolation of animal or human tissues
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20040078054A1 (en) * 1998-06-05 2004-04-22 Broncus Technologies, Inc. Method for lung volume reduction
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20060052669A1 (en) * 2003-01-24 2006-03-09 Hart Charles C Internal tissue retractor
US7011094B2 (en) 2001-03-02 2006-03-14 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US20060155217A1 (en) * 2002-09-24 2006-07-13 Devore Lauri J Device and method for measuring the diameter of an air passageway
US20060235467A1 (en) * 2002-04-16 2006-10-19 Devore Lauri J Removable anchored lung volume reduction device and methods
US20070185531A1 (en) * 2001-10-25 2007-08-09 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US20070235846A1 (en) * 2006-04-01 2007-10-11 Stats Chippac Ltd. Integrated circuit package system with net spacer
US7377278B2 (en) 2003-06-05 2008-05-27 Portaero, Inc. Intra-thoracic collateral ventilation bypass system and method
US7398782B2 (en) 2004-11-19 2008-07-15 Portaero, Inc. Method for pulmonary drug delivery
US7406963B2 (en) 2006-01-17 2008-08-05 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve and method
US20080188809A1 (en) * 2003-05-07 2008-08-07 Portaero, Inc. Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis
US7426929B2 (en) 2003-05-20 2008-09-23 Portaero, Inc. Intra/extra-thoracic collateral ventilation bypass system and method
US7434578B2 (en) 2002-05-17 2008-10-14 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US20090012545A1 (en) * 2005-07-14 2009-01-08 Idx Medical, Ltd. Apparatus and Methods for Occluding a Hallow Anatomical Structure
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US20090076526A1 (en) * 2007-09-18 2009-03-19 Alexandra Rousseau Compression, Banding and Percutaneous Airway Ligation of Emphysematous Lung Tissue
US7533667B2 (en) 2003-05-29 2009-05-19 Portaero, Inc. Methods and devices to assist pulmonary decompression
US7549984B2 (en) 2004-06-16 2009-06-23 Pneumrx, Inc. Method of compressing a portion of a lung
US7645285B2 (en) 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US7682332B2 (en) 2003-07-15 2010-03-23 Portaero, Inc. Methods to accelerate wound healing in thoracic anastomosis applications
US7757692B2 (en) 2001-09-11 2010-07-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US7766938B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US7798147B2 (en) 2001-03-02 2010-09-21 Pulmonx Corporation Bronchial flow control devices with membrane seal
US7814912B2 (en) 2002-11-27 2010-10-19 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US7824366B2 (en) 2004-12-10 2010-11-02 Portaero, Inc. Collateral ventilation device with chest tube/evacuation features and method
US20110021879A1 (en) * 2009-07-21 2011-01-27 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US7896008B2 (en) 2003-06-03 2011-03-01 Portaero, Inc. Lung reduction system
US7909803B2 (en) 2008-02-19 2011-03-22 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8062315B2 (en) 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
US8104474B2 (en) 2005-08-23 2012-01-31 Portaero, Inc. Collateral ventilation bypass system with retention features
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US8142455B2 (en) 2006-03-13 2012-03-27 Pneumrx, Inc. Delivery of minimally invasive lung volume reduction devices
US8157818B2 (en) 2005-08-01 2012-04-17 Ension, Inc. Integrated medical apparatus for non-traumatic grasping, manipulating and closure of tissue
US8163034B2 (en) 2007-05-11 2012-04-24 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US8206684B2 (en) 2004-02-27 2012-06-26 Pulmonx Corporation Methods and devices for blocking flow through collateral pathways in the lung
US8220460B2 (en) 2004-11-19 2012-07-17 Portaero, Inc. Evacuation device and method for creating a localized pleurodesis
US8251067B2 (en) 2001-03-02 2012-08-28 Pulmonx Corporation Bronchial flow control devices with membrane seal
US8336540B2 (en) 2008-02-19 2012-12-25 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US8347881B2 (en) 2009-01-08 2013-01-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US8454708B2 (en) 2006-03-31 2013-06-04 Spiration, Inc. Articulable anchor
EP2599461A1 (en) * 2011-12-02 2013-06-05 Rainer Zotz A device for performing diagnostics and/or therapy
WO2013079712A2 (en) 2011-12-02 2013-06-06 Rainer Zotz A device for performing diagnostics and/or therapy
US8475389B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
US8518053B2 (en) 2009-02-11 2013-08-27 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US8636754B2 (en) 2010-11-11 2014-01-28 Atricure, Inc. Clip applicator
US8721734B2 (en) 2009-05-18 2014-05-13 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US8740921B2 (en) 2006-03-13 2014-06-03 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US9017349B2 (en) 2010-10-27 2015-04-28 Atricure, Inc. Appendage clamp deployment assist device
US9066741B2 (en) 2010-11-01 2015-06-30 Atricure, Inc. Robotic toolkit
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US9265486B2 (en) 2011-08-15 2016-02-23 Atricure, Inc. Surgical device
US9282973B2 (en) 2012-01-20 2016-03-15 Atricure, Inc. Clip deployment tool and associated methods
USRE45921E1 (en) 2000-03-23 2016-03-15 Spiration, Inc. Tissue resection device, system, and method
US9393023B2 (en) 2009-01-13 2016-07-19 Atricure, Inc. Apparatus and methods for deploying a clip to occlude an anatomical structure
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US9408659B2 (en) 2007-04-02 2016-08-09 Atricure, Inc. Surgical instrument with separate tool head and method of use
US9656063B2 (en) 2004-06-18 2017-05-23 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US9737403B2 (en) 2006-03-03 2017-08-22 Mardil, Inc. Self-adjusting attachment structure for a cardiac support device
US10064723B2 (en) 2012-10-12 2018-09-04 Mardil, Inc. Cardiac treatment system and method
US10098640B2 (en) 2001-12-04 2018-10-16 Atricure, Inc. Left atrial appendage devices and methods
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
US11998212B2 (en) 2013-11-21 2024-06-04 Atricure, Inc. Occlusion clip
US12004752B2 (en) 2012-11-21 2024-06-11 Atricure, Inc. Occlusion clip
US12285345B2 (en) 2021-07-20 2025-04-29 Apreo Health, Inc. Endobronchial implants and related technology

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5702343A (en) * 1996-10-02 1997-12-30 Acorn Medical, Inc. Cardiac reinforcement device
US6123663A (en) 1996-07-04 2000-09-26 Rebuffat; Carlo Surgical appliance for the treatment of pulmonary emphysema
US6241654B1 (en) * 1999-07-07 2001-06-05 Acorn Cardiovasculr, Inc. Cardiac reinforcement devices and methods

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6123663A (en) 1996-07-04 2000-09-26 Rebuffat; Carlo Surgical appliance for the treatment of pulmonary emphysema
US5702343A (en) * 1996-10-02 1997-12-30 Acorn Medical, Inc. Cardiac reinforcement device
US6241654B1 (en) * 1999-07-07 2001-06-05 Acorn Cardiovasculr, Inc. Cardiac reinforcement devices and methods

Cited By (204)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030212452A1 (en) * 1997-09-16 2003-11-13 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20020095209A1 (en) * 1997-09-16 2002-07-18 Gholam-Reza Zadno-Azizi Body fluid flow control device
US20020077696A1 (en) * 1997-09-16 2002-06-20 Gholam-Reza Zadno-Azizi Body fluid flow control device
US7276077B2 (en) 1997-09-16 2007-10-02 Emphasys Medical, Inc. Body fluid flow control device
US7033387B2 (en) 1997-09-16 2006-04-25 Emphasys Medical, Inc. Body fluid flow control device
US20030199972A1 (en) * 1997-09-16 2003-10-23 Gholam-Reza Zadno-Azizi Body fluid flow control device
US6997189B2 (en) 1998-06-05 2006-02-14 Broncus Technologies, Inc. Method for lung volume reduction
US20040078054A1 (en) * 1998-06-05 2004-04-22 Broncus Technologies, Inc. Method for lung volume reduction
US6679264B1 (en) 2000-03-04 2004-01-20 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US6904909B2 (en) 2000-03-04 2005-06-14 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US8474460B2 (en) 2000-03-04 2013-07-02 Pulmonx Corporation Implanted bronchial isolation devices and methods
US20030192551A1 (en) * 2000-03-04 2003-10-16 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US20030070683A1 (en) * 2000-03-04 2003-04-17 Deem Mark E. Methods and devices for use in performing pulmonary procedures
US7165548B2 (en) 2000-03-04 2007-01-23 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US7662181B2 (en) 2000-03-04 2010-02-16 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US6840243B2 (en) 2000-03-04 2005-01-11 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
US8357139B2 (en) 2000-03-04 2013-01-22 Pulmonx Corporation Methods and devices for use in performing pulmonary procedures
US6901927B2 (en) 2000-03-04 2005-06-07 Emphasys Medical, Inc. Methods and devices for use in performing pulmonary procedures
USRE45921E1 (en) 2000-03-23 2016-03-15 Spiration, Inc. Tissue resection device, system, and method
US6514290B1 (en) * 2000-03-31 2003-02-04 Broncus Technologies, Inc. Lung elastic recoil restoring or tissue compressing device and method
US8251067B2 (en) 2001-03-02 2012-08-28 Pulmonx Corporation Bronchial flow control devices with membrane seal
US7798147B2 (en) 2001-03-02 2010-09-21 Pulmonx Corporation Bronchial flow control devices with membrane seal
US20040074491A1 (en) * 2001-03-02 2004-04-22 Michael Hendricksen Delivery methods and devices for implantable bronchial isolation devices
US7011094B2 (en) 2001-03-02 2006-03-14 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US7182772B2 (en) * 2001-07-10 2007-02-27 Spiration, Inc. Constriction device including fixation structure
US20030069488A1 (en) * 2001-07-10 2003-04-10 Spiration, Inc. Constriction device including fixation structure
US7757692B2 (en) 2001-09-11 2010-07-20 Spiration, Inc. Removable lung reduction devices, systems, and methods
US8414655B2 (en) 2001-09-11 2013-04-09 Spiration, Inc. Removable lung reduction devices, systems, and methods
US8974484B2 (en) 2001-09-11 2015-03-10 Spiration, Inc. Removable lung reduction devices, systems, and methods
US7854228B2 (en) 2001-10-11 2010-12-21 Pulmonx Corporation Bronchial flow control devices and methods of use
US6941950B2 (en) 2001-10-11 2005-09-13 Emphasys Medical, Inc. Bronchial flow control devices and methods of use
US20030070682A1 (en) * 2001-10-11 2003-04-17 Wilson Peter M. Bronchial flow control devices and methods of use
US20050166925A1 (en) * 2001-10-11 2005-08-04 Emphasys Medical, Inc., A California Corporation Bronchial flow control devices and methods of use
US20050145253A1 (en) * 2001-10-11 2005-07-07 Emphasys Medical, Inc., A Delaware Corporation Bronchial flow control devices and methods of use
US7896887B2 (en) 2001-10-25 2011-03-01 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US8986336B2 (en) 2001-10-25 2015-03-24 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US20070185531A1 (en) * 2001-10-25 2007-08-09 Spiration, Inc. Apparatus and method for deployment of a bronchial obstruction device
US10524791B2 (en) 2001-12-04 2020-01-07 Atricure, Inc. Left atrial appendage devices and methods
US10098640B2 (en) 2001-12-04 2018-10-16 Atricure, Inc. Left atrial appendage devices and methods
US7942931B2 (en) 2002-02-21 2011-05-17 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US6929637B2 (en) 2002-02-21 2005-08-16 Spiration, Inc. Device and method for intra-bronchial provision of a therapeutic agent
US20080249503A1 (en) * 2002-03-08 2008-10-09 Fields Antony J Methods and devices for lung treatment
US20030228344A1 (en) * 2002-03-08 2003-12-11 Fields Antony J. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US20060283462A1 (en) * 2002-03-08 2006-12-21 Fields Antony J Methods and devices for inducing collapse in lung regions fed by collateral pathways
US7412977B2 (en) 2002-03-08 2008-08-19 Emphasys Medical, Inc. Methods and devices for inducing collapse in lung regions fed by collateral pathways
US8021385B2 (en) 2002-03-20 2011-09-20 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8926647B2 (en) 2002-03-20 2015-01-06 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US8177805B2 (en) 2002-03-20 2012-05-15 Spiration, Inc. Removable anchored lung volume reduction devices and methods
US20060235467A1 (en) * 2002-04-16 2006-10-19 Devore Lauri J Removable anchored lung volume reduction device and methods
US7527634B2 (en) 2002-05-14 2009-05-05 University Of Pittsburgh Device and method of use for functional isolation of animal or human tissues
US8007504B2 (en) 2002-05-14 2011-08-30 University Of Pittsburgh Of The Commonwealth System Of Higher Education Device and method of use for functional isolation of animal or human tissues
US20040030335A1 (en) * 2002-05-14 2004-02-12 University Of Pittsburgh Device and method of use for functional isolation of animal or human tissues
US20090182326A1 (en) * 2002-05-14 2009-07-16 Marco Zenati Device and method of use for functional isolation of animal or human tissues
US7842061B2 (en) 2002-05-17 2010-11-30 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US7875048B2 (en) 2002-05-17 2011-01-25 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US8956319B2 (en) 2002-05-17 2015-02-17 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US8257381B2 (en) 2002-05-17 2012-09-04 Spiration, Inc. One-way valve devices for anchored implantation in a lung
US7434578B2 (en) 2002-05-17 2008-10-14 Spiration, Inc. Methods of achieving lung volume reduction with removable anchored devices
US20040039250A1 (en) * 2002-05-28 2004-02-26 David Tholfsen Guidewire delivery of implantable bronchial isolation devices in accordance with lung treatment
US20050066974A1 (en) * 2002-05-28 2005-03-31 Antony Fields Modification of lung region flow dynamics using flow control devices implanted in bronchial wall channels
US20060155217A1 (en) * 2002-09-24 2006-07-13 Devore Lauri J Device and method for measuring the diameter of an air passageway
US7476203B2 (en) 2002-09-24 2009-01-13 Spiration, Inc. Device and method for measuring the diameter of an air passageway
US7814912B2 (en) 2002-11-27 2010-10-19 Pulmonx Corporation Delivery methods and devices for implantable bronchial isolation devices
US20090227844A1 (en) * 2003-01-24 2009-09-10 Applied Medical Resources Corporation Internal tissue retractor
US20060052669A1 (en) * 2003-01-24 2006-03-09 Hart Charles C Internal tissue retractor
US8308638B2 (en) 2003-01-24 2012-11-13 Applied Medical Resources Corporation Internal tissue retractor
US20040200484A1 (en) * 2003-04-08 2004-10-14 Springmeyer Steven C. Bronchoscopic lung volume reduction method
US8079368B2 (en) 2003-04-08 2011-12-20 Spiration, Inc. Bronchoscopic lung volume reduction method
US7100616B2 (en) 2003-04-08 2006-09-05 Spiration, Inc. Bronchoscopic lung volume reduction method
US8667973B2 (en) 2003-04-08 2014-03-11 Spiration, Inc. Bronchoscopic lung volume reduction method
US20060249164A1 (en) * 2003-04-08 2006-11-09 Springmeyer Steven C Bronchoscopic lung volume reduction method
US7497857B2 (en) 2003-04-29 2009-03-03 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US7871409B2 (en) 2003-04-29 2011-01-18 Medtronic, Inc. Endocardial dispersive electrode for use with a monopolar RF ablation pen
US8029492B2 (en) 2003-05-07 2011-10-04 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US7828789B2 (en) 2003-05-07 2010-11-09 Portaero, Inc. Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis
US7811274B2 (en) 2003-05-07 2010-10-12 Portaero, Inc. Method for treating chronic obstructive pulmonary disease
US20080188809A1 (en) * 2003-05-07 2008-08-07 Portaero, Inc. Device and method for creating a localized pleurodesis and treating a lung through the localized pleurodesis
US7426929B2 (en) 2003-05-20 2008-09-23 Portaero, Inc. Intra/extra-thoracic collateral ventilation bypass system and method
US7789083B2 (en) 2003-05-20 2010-09-07 Portaero, Inc. Intra/extra thoracic system for ameliorating a symptom of chronic obstructive pulmonary disease
US7533667B2 (en) 2003-05-29 2009-05-19 Portaero, Inc. Methods and devices to assist pulmonary decompression
US20040243393A1 (en) * 2003-05-29 2004-12-02 Microsoft Corporation Semantic object synchronous understanding implemented with speech application language tags
US7896008B2 (en) 2003-06-03 2011-03-01 Portaero, Inc. Lung reduction system
US7377278B2 (en) 2003-06-05 2008-05-27 Portaero, Inc. Intra-thoracic collateral ventilation bypass system and method
US7753052B2 (en) 2003-06-05 2010-07-13 Portaero, Inc. Intra-thoracic collateral ventilation bypass system
US8323230B2 (en) 2003-07-15 2012-12-04 Portaero, Inc. Methods and devices to accelerate wound healing in thoracic anastomosis applications
US7682332B2 (en) 2003-07-15 2010-03-23 Portaero, Inc. Methods to accelerate wound healing in thoracic anastomosis applications
US20090182369A1 (en) * 2003-08-08 2009-07-16 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US9622752B2 (en) 2003-08-08 2017-04-18 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7533671B2 (en) 2003-08-08 2009-05-19 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8974527B2 (en) 2003-08-08 2015-03-10 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US7887585B2 (en) 2003-08-08 2011-02-15 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US8444690B2 (en) 2003-08-08 2013-05-21 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20110208228A1 (en) * 2003-08-08 2011-08-25 Spiration, Inc. Bronchoscopic repair of air leaks in a lung
US20050137714A1 (en) * 2003-08-08 2005-06-23 Gonzalez Hugo X. Bronchoscopic repair of air leaks in a lung
US8206684B2 (en) 2004-02-27 2012-06-26 Pulmonx Corporation Methods and devices for blocking flow through collateral pathways in the lung
US7645285B2 (en) 2004-05-26 2010-01-12 Idx Medical, Ltd Apparatus and methods for occluding a hollow anatomical structure
US7775968B2 (en) 2004-06-14 2010-08-17 Pneumrx, Inc. Guided access to lung tissues
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US7549984B2 (en) 2004-06-16 2009-06-23 Pneumrx, Inc. Method of compressing a portion of a lung
US9656063B2 (en) 2004-06-18 2017-05-23 Medtronic, Inc. Method and system for placement of electrical lead inside heart
US7766938B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US9211181B2 (en) 2004-11-19 2015-12-15 Pulmonx Corporation Implant loading device and system
US11083556B2 (en) 2004-11-19 2021-08-10 Pulmonx Corporation Implant loading device and system
US8388682B2 (en) 2004-11-19 2013-03-05 Pulmonx Corporation Bronchial flow control devices and methods of use
US9872755B2 (en) 2004-11-19 2018-01-23 Pulmonx Corporation Implant loading device and system
US8220460B2 (en) 2004-11-19 2012-07-17 Portaero, Inc. Evacuation device and method for creating a localized pleurodesis
US7771472B2 (en) 2004-11-19 2010-08-10 Pulmonx Corporation Bronchial flow control devices and methods of use
US12064331B2 (en) 2004-11-19 2024-08-20 Pulmonx Corporation Implant loading device and system
US7398782B2 (en) 2004-11-19 2008-07-15 Portaero, Inc. Method for pulmonary drug delivery
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
US10034999B2 (en) 2004-11-23 2018-07-31 Pneumrx, Inc. Steerable device for accessing a target site and methods
US7824366B2 (en) 2004-12-10 2010-11-02 Portaero, Inc. Collateral ventilation device with chest tube/evacuation features and method
US8876791B2 (en) 2005-02-25 2014-11-04 Pulmonx Corporation Collateral pathway treatment using agent entrained by aspiration flow current
US10166024B2 (en) 2005-07-14 2019-01-01 Idx Medical, Ltd. Apparatus and methods for occluding a hollow anatomical structure
US20090012545A1 (en) * 2005-07-14 2009-01-08 Idx Medical, Ltd. Apparatus and Methods for Occluding a Hallow Anatomical Structure
US8157818B2 (en) 2005-08-01 2012-04-17 Ension, Inc. Integrated medical apparatus for non-traumatic grasping, manipulating and closure of tissue
US8104474B2 (en) 2005-08-23 2012-01-31 Portaero, Inc. Collateral ventilation bypass system with retention features
US7686013B2 (en) 2006-01-17 2010-03-30 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US7726305B2 (en) 2006-01-17 2010-06-01 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve
US7406963B2 (en) 2006-01-17 2008-08-05 Portaero, Inc. Variable resistance pulmonary ventilation bypass valve and method
US10806580B2 (en) 2006-03-03 2020-10-20 Mardil, Inc. Self-adjusting attachment structure for a cardiac support device
US9737403B2 (en) 2006-03-03 2017-08-22 Mardil, Inc. Self-adjusting attachment structure for a cardiac support device
US9474533B2 (en) 2006-03-13 2016-10-25 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8740921B2 (en) 2006-03-13 2014-06-03 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8668707B2 (en) 2006-03-13 2014-03-11 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US10226257B2 (en) 2006-03-13 2019-03-12 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US10188397B2 (en) 2006-03-13 2019-01-29 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8932310B2 (en) 2006-03-13 2015-01-13 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US9782558B2 (en) 2006-03-13 2017-10-10 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US8142455B2 (en) 2006-03-13 2012-03-27 Pneumrx, Inc. Delivery of minimally invasive lung volume reduction devices
US8282660B2 (en) 2006-03-13 2012-10-09 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US8157823B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402971B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Minimally invasive lung volume reduction devices, methods, and systems
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US9402632B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US8647392B2 (en) 2006-03-31 2014-02-11 Spiration, Inc. Articulable anchor
US8454708B2 (en) 2006-03-31 2013-06-04 Spiration, Inc. Articulable anchor
US9198669B2 (en) 2006-03-31 2015-12-01 Spiration, Inc. Articulable anchor
US20070235846A1 (en) * 2006-04-01 2007-10-11 Stats Chippac Ltd. Integrated circuit package system with net spacer
US9408659B2 (en) 2007-04-02 2016-08-09 Atricure, Inc. Surgical instrument with separate tool head and method of use
US8163034B2 (en) 2007-05-11 2012-04-24 Portaero, Inc. Methods and devices to create a chemically and/or mechanically localized pleurodesis
US7931641B2 (en) 2007-05-11 2011-04-26 Portaero, Inc. Visceral pleura ring connector
US8062315B2 (en) 2007-05-17 2011-11-22 Portaero, Inc. Variable parietal/visceral pleural coupling
US8728093B2 (en) * 2007-09-18 2014-05-20 Boston Scientific Scimed, Inc. Compression, banding and percutaneous airway ligation of emphysematous lung tissue
US20090076526A1 (en) * 2007-09-18 2009-03-19 Alexandra Rousseau Compression, Banding and Percutaneous Airway Ligation of Emphysematous Lung Tissue
US8136230B2 (en) 2007-10-12 2012-03-20 Spiration, Inc. Valve loader method, system, and apparatus
US9326873B2 (en) 2007-10-12 2016-05-03 Spiration, Inc. Valve loader method, system, and apparatus
US8043301B2 (en) 2007-10-12 2011-10-25 Spiration, Inc. Valve loader method, system, and apparatus
US8252003B2 (en) 2008-02-19 2012-08-28 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US8453638B2 (en) 2008-02-19 2013-06-04 Portaero, Inc. One-piece pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8336540B2 (en) 2008-02-19 2012-12-25 Portaero, Inc. Pneumostoma management device and method for treatment of chronic obstructive pulmonary disease
US8365722B2 (en) 2008-02-19 2013-02-05 Portaero, Inc. Multi-layer pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US7927324B2 (en) 2008-02-19 2011-04-19 Portaero, Inc. Aspirator and method for pneumostoma management
US8453637B2 (en) 2008-02-19 2013-06-04 Portaero, Inc. Pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8347880B2 (en) 2008-02-19 2013-01-08 Potaero, Inc. Pneumostoma management system with secretion management features for treatment of chronic obstructive pulmonary disease
US8474449B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Variable length pneumostoma management system for treatment of chronic obstructive pulmonary disease
US8475389B2 (en) 2008-02-19 2013-07-02 Portaero, Inc. Methods and devices for assessment of pneumostoma function
US8348906B2 (en) 2008-02-19 2013-01-08 Portaero, Inc. Aspirator for pneumostoma management
US8231581B2 (en) 2008-02-19 2012-07-31 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US8430094B2 (en) 2008-02-19 2013-04-30 Portaero, Inc. Flexible pneumostoma management system and methods for treatment of chronic obstructive pulmonary disease
US8021320B2 (en) 2008-02-19 2011-09-20 Portaero, Inc. Self-sealing device and method for delivery of a therapeutic agent through a pneumostoma
US8464708B2 (en) 2008-02-19 2013-06-18 Portaero, Inc. Pneumostoma management system having a cosmetic and/or protective cover
US7909803B2 (en) 2008-02-19 2011-03-22 Portaero, Inc. Enhanced pneumostoma management device and methods for treatment of chronic obstructive pulmonary disease
US8491602B2 (en) 2008-02-19 2013-07-23 Portaero, Inc. Single-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US8506577B2 (en) 2008-02-19 2013-08-13 Portaero, Inc. Two-phase surgical procedure for creating a pneumostoma to treat chronic obstructive pulmonary disease
US10058331B2 (en) 2008-09-12 2018-08-28 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US10285707B2 (en) 2008-09-12 2019-05-14 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US9192403B2 (en) 2008-09-12 2015-11-24 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
US8347881B2 (en) 2009-01-08 2013-01-08 Portaero, Inc. Pneumostoma management device with integrated patency sensor and method
US9393023B2 (en) 2009-01-13 2016-07-19 Atricure, Inc. Apparatus and methods for deploying a clip to occlude an anatomical structure
US8518053B2 (en) 2009-02-11 2013-08-27 Portaero, Inc. Surgical instruments for creating a pneumostoma and treating chronic obstructive pulmonary disease
US8721734B2 (en) 2009-05-18 2014-05-13 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US8469883B2 (en) 2009-07-21 2013-06-25 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US12161317B2 (en) 2009-07-21 2024-12-10 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US20110021879A1 (en) * 2009-07-21 2011-01-27 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US11278271B2 (en) 2009-07-21 2022-03-22 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US9867604B2 (en) 2009-07-21 2018-01-16 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US10456125B2 (en) 2009-07-21 2019-10-29 Applied Medical Resources Corporation Surgical access device comprising internal retractor
US11883035B2 (en) 2010-10-27 2024-01-30 Atricure, Inc. Appendage clamp deployment assist device
US9017349B2 (en) 2010-10-27 2015-04-28 Atricure, Inc. Appendage clamp deployment assist device
US9066741B2 (en) 2010-11-01 2015-06-30 Atricure, Inc. Robotic toolkit
US8636754B2 (en) 2010-11-11 2014-01-28 Atricure, Inc. Clip applicator
US8795241B2 (en) 2011-05-13 2014-08-05 Spiration, Inc. Deployment catheter
US9265486B2 (en) 2011-08-15 2016-02-23 Atricure, Inc. Surgical device
US10350048B2 (en) 2011-09-23 2019-07-16 Pulmonx Corporation Implant loading device and system
EP2599461A1 (en) * 2011-12-02 2013-06-05 Rainer Zotz A device for performing diagnostics and/or therapy
WO2013079712A2 (en) 2011-12-02 2013-06-06 Rainer Zotz A device for performing diagnostics and/or therapy
WO2013079712A3 (en) * 2011-12-02 2013-10-03 Rainer Zotz A device for performing diagnostics and/or therapy
US9282973B2 (en) 2012-01-20 2016-03-15 Atricure, Inc. Clip deployment tool and associated methods
US10064723B2 (en) 2012-10-12 2018-09-04 Mardil, Inc. Cardiac treatment system and method
US11406500B2 (en) 2012-10-12 2022-08-09 Diaxamed, Llc Cardiac treatment system and method
US10420644B2 (en) 2012-10-12 2019-09-24 Mardil, Inc. Cardiac treatment system and method
US12193680B2 (en) 2012-11-21 2025-01-14 Atricure, Inc. Occlusion clip
US12004752B2 (en) 2012-11-21 2024-06-11 Atricure, Inc. Occlusion clip
US11998211B2 (en) 2013-11-21 2024-06-04 Atricure, Inc. Occlusion clip
US12076019B2 (en) 2013-11-21 2024-09-03 Atricure, Inc. Occlusion clip
US11998212B2 (en) 2013-11-21 2024-06-04 Atricure, Inc. Occlusion clip
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
US12285345B2 (en) 2021-07-20 2025-04-29 Apreo Health, Inc. Endobronchial implants and related technology

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