WO2004035736A3 - Halogenated selective androgen receptor modulators and methods of use thereof - Google Patents

Halogenated selective androgen receptor modulators and methods of use thereof Download PDF

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Publication number
WO2004035736A3
WO2004035736A3 PCT/US2003/032507 US0332507W WO2004035736A3 WO 2004035736 A3 WO2004035736 A3 WO 2004035736A3 US 0332507 W US0332507 W US 0332507W WO 2004035736 A3 WO2004035736 A3 WO 2004035736A3
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WO
WIPO (PCT)
Prior art keywords
androgen receptor
cancer
androgen
osteoporosis
treatment
Prior art date
Application number
PCT/US2003/032507
Other languages
French (fr)
Other versions
WO2004035736A2 (en
Inventor
James T Dalton
Duane D Miller
Donghua Yin
Yali He
Mitchell S Steiner
Karen A Veverka
Original Assignee
Univ Tennessee Res Foundation
James T Dalton
Duane D Miller
Donghua Yin
Yali He
Mitchell S Steiner
Karen A Veverka
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/270,732 external-priority patent/US6998500B2/en
Priority to MXPA05004076A priority Critical patent/MXPA05004076A/en
Priority to CA002502355A priority patent/CA2502355A1/en
Priority to AT03777595T priority patent/ATE430125T1/en
Priority to BR0314891-2A priority patent/BR0314891A/en
Priority to DE60327456T priority patent/DE60327456D1/en
Priority to EP03777595A priority patent/EP1558565B1/en
Priority to CNA2007100842211A priority patent/CN100999481A/en
Priority to KR1020107029192A priority patent/KR101107031B1/en
Application filed by Univ Tennessee Res Foundation, James T Dalton, Duane D Miller, Donghua Yin, Yali He, Mitchell S Steiner, Karen A Veverka filed Critical Univ Tennessee Res Foundation
Priority to CN200380106307XA priority patent/CN1726185B/en
Priority to DK03777595T priority patent/DK1558565T3/en
Priority to CNA2007101041899A priority patent/CN101062023A/en
Priority to AU2003287074A priority patent/AU2003287074B2/en
Priority to EA200500648A priority patent/EA011744B1/en
Priority to SI200331644T priority patent/SI1558565T1/en
Priority to JP2005501406A priority patent/JP4764719B2/en
Publication of WO2004035736A2 publication Critical patent/WO2004035736A2/en
Publication of WO2004035736A3 publication Critical patent/WO2004035736A3/en
Priority to HR20050334A priority patent/HRP20050334A2/en
Priority to HK06101428.4A priority patent/HK1080070A1/en
Priority to IL182880A priority patent/IL182880A0/en
Priority to HR20070457A priority patent/HRP20070457A2/en
Priority to IL190931A priority patent/IL190931A0/en

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    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4706—4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
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    • A—HUMAN NECESSITIES
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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/16—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C07C255/60—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton at least one of the singly-bound nitrogen atoms being acylated
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    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems

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  • Pregnancy & Childbirth (AREA)
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Abstract

This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor. The SARM compounds, either alone or as a composition, are useful for a) male contraception; b) treatment of a variety of hormone-related conditions, for example conditions associated with Androgen Decline in Aging Male (ADAM), such as fatigue, depression, decreased libido, sexual dysfunction, erectile dysfunction, hypogonadism, osteoporosis, hair loss, anemia, obesity, sarcopenia, osteopenia, osteoporosis, benign prostate hyperplasia, alterations in mood and cognition and prostate cancer; c) treatment of conditions associated with Androgen Decline in Female (ADIF), such as sexual dysfunction, decreased sexual libido, hypogonadism, sarcopenia, osteopenia, osteoporosis, alterations in cognition and mood, depression, anemia, hair loss, obesity, endometriosis, breast cancer, uterine cancer and ovarian cancer; d) treatment and/or prevention of acute and/or chronic muscular wasting conditions; e) preventing and/or treating dry eye conditions; f) oral androgen replacement therapy; g) decreasing the incidence of, halting or causing a regression of prostate cancer; and/or h) inducing apoptosis in a cancer cell.
PCT/US2003/032507 2000-08-24 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof WO2004035736A2 (en)

Priority Applications (20)

Application Number Priority Date Filing Date Title
JP2005501406A JP4764719B2 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulator and method of use thereof
DK03777595T DK1558565T3 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods for their preparation
AT03777595T ATE430125T1 (en) 2002-10-16 2003-10-14 HALOGENATED SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD FOR USE THEREOF
BR0314891-2A BR0314891A (en) 2002-10-16 2003-10-14 Selective halogenated androgen receptor modulators and their methods of use
DE60327456T DE60327456D1 (en) 2002-10-16 2003-10-14 HALOGENATED SELECTIVE ANDROGEN RECEPTOR MODULATORS AND METHOD FOR THEIR USE
EP03777595A EP1558565B1 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof
CNA2007100842211A CN100999481A (en) 2002-10-16 2003-10-14 Selective androgen receptor modulators and methods of use thereof
AU2003287074A AU2003287074B2 (en) 2000-08-24 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof
CA002502355A CA2502355A1 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof
CN200380106307XA CN1726185B (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and using method thereof
CNA2007101041899A CN101062023A (en) 2002-10-16 2003-10-14 Selective androgen receptor modulators and methods of use thereof
MXPA05004076A MXPA05004076A (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof.
KR1020107029192A KR101107031B1 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof
EA200500648A EA011744B1 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof
SI200331644T SI1558565T1 (en) 2002-10-16 2003-10-14 Halogenated selective androgen receptor modulators and methods of use thereof
HR20050334A HRP20050334A2 (en) 2002-10-16 2005-04-14 Halogenated selective androgen receptor modulators and methods of use thereof
HK06101428.4A HK1080070A1 (en) 2002-10-16 2006-02-02 Halogenated selective androgen receptor modulators and methods of use thereof
IL182880A IL182880A0 (en) 2002-10-16 2007-04-30 Halogenated selective androgen receptor modulators and methods of use thereof
HR20070457A HRP20070457A2 (en) 2002-10-16 2007-10-01 Halogenated selective androgen receptor modulators and methods of use thereof
IL190931A IL190931A0 (en) 2002-10-16 2008-04-17 Halogenated selective androgen receptor modulators and methods of use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/270,732 US6998500B2 (en) 2000-08-24 2002-10-16 Selective androgen receptor modulators and methods of use thereof
US10/270,732 2002-10-16
US10/371,213 US7026500B2 (en) 2000-08-24 2003-02-24 Halogenated selective androgen receptor modulators and methods of use thereof
US10/371,213 2003-02-24

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WO2004035736A2 WO2004035736A2 (en) 2004-04-29
WO2004035736A3 true WO2004035736A3 (en) 2004-07-15

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